脑星形细胞瘤中P53蛋白异常表达

Aberrant expression of p53 protein in human brain astrocytoma

利用P53单抗免疫组化技术检测了80例不同级别的脑星形细胞瘤组织,并探讨了P53蛋白异常表达与星形细胞瘤预后的关系。结果,80例中有26例免疫组化阳性,高分级者的阳性率明显高干低分级者(P<0.01)。该80例中术后生存期低于2年者的阳性率明显高于2年及以上者(P<0.005),Ⅲ～Ⅳ级者生存期低于1年者的阳性率明显高于1年及以上者(P<0.025)。结果提示:P53蛋白异常表达与星形细胞瘤的级别和预后有关,P53单抗免疫组化检测可作为脑星形细胞瘤的病理分级工具及预后指标。

Eighty samples of astrocytomas of differ- ent degree were examined immunohis- tochemically for the expression of p53 protein by using monoclonal antibody to p53 protein. The prognosis of the patients with astrocy- toma and p53 expression were investigated. 26 of the 80 tumors revealed positive staining. Of the 80 cases, the patients with survival less than 2 years after operation had higher posi- tive rate than those with survival longer than 2 years P<0.005. In 40 patients with tu- mors of grades Ⅲ and Ⅳ, the positive-rate of