肝移植术后中心静脉导管相关性脓毒症的危险因素分析

Risk factors of catheter-related sepsis after liver transplantation

目的分析肝移植术后中心静脉导管相关性脓毒症(CRS)的发生情况及危险因素。方法回顾性分析260例肝移植患者的临床资料。选取围手术期25个独立变量,经单变量分析及Logistic回归分析,筛选与术后CRS相关的危险因素。结果肝移植术后CRS的感染率为9.2%。最常见的致病菌是表皮葡萄球菌和金黄色葡萄球菌等革兰阳性球菌。置管时间、术后白细胞减少和术前肝功能Child-Pugh分级是影响肝移植术后CRS发生的独立危险因素。结论肝移植术后CRS的感染率较高,针对危险因素采取有针对性的预防措施将有助于降低CRS的发生率。

Objective To investigate the incidence and risk factors of catheter - related sepsis （CRS） after liver transplantation. Methods The clinical data of 260 cases of liver transplantation were analyzed retrospectively. Twenty -five independent variables related to perioperative conditions were analyzed. Univariate analysis and Logistic regression were performed to screening the factors correlating to CRS after liver transplantation. Results The infection rate of CRS after liver transplantation was 9.2%. The most common organisms were staphyloccus aureus and staphylococcus epidemis. It was identified that duration of catheter insertion, postoperative leukopenia and Child-Pugh evaluation before operation were independent risk factors of CRS after liver transplantation. Conclusion The liver transplanta- tion recipients are susccptible to CRS. Preventive measures aimed at risk factors could help reduce the incidence of postoperative CRS.