氯丙嗪在离子液体BMIMPF_6修饰玻碳电极上的伏安行为

Voltammetric Behavior of Chlorpromazine at Glassy Carbon Electrodes Modified with Room Temperature Ionic Liquid 1-Buty-3-methylimidazolium Hexafluorophate

对氯丙嗪（CPZ）在离子液体BMIMPF6修饰玻碳电极（BMIMPF6／GC）上的伏安行为进行了研究。发现CPZ在该修饰电极上于0．65V左右产生氧化还原峰，峰的可逆性比玻碳电极（GC）有较大改进，其电极过程为吸附控制。在0．050mol／L磷酸缓冲溶液（pH4）中，CPZ在BMIMPF6／GC上的氧化峰的峰电流约为GC上的2倍。在优化实验条件的基础上，采用微分脉冲伏安法对不同浓度CPZ溶液进行了测定。结果表明，CPZ在BMIMPF6／GC上的氧化峰电流与浓度在5．6×10^-9～3．0×10^-5mol／L范围内有线性关系。将此方法用于尿样的测定，其加入回收率为97％左右。用3种电极测定了CPZ的表观扩散系数，其大小为D（BMIMPF6／GC）〉D（OMIMBF6／GC）〉D（CC），这与电极表面积变化及膜内扩散有一定关系。

The voltammetric behavior of chlorpromazine has been studied at ionic liquid 1-butyl-3-methylimidazolium hexafluorophate modified glassy carbon electrode （BMIMPF6/GC）. Chlorpromazine can exhibit redox peaks at about 0.65 V. The anodic peak current of chlorpromazine at BMIMPF6/GC is about two times as large as that at GC electrode in a 0.050 mol/L phosphate buffer solution （pH≈4）. At the same time, the peaks become more reversible. The factors influencing the response were optimized. Under the selected conditions, the peak current was linear to chlorpromazine concentration in the range of 5.6×10^-9-3.0×10^-5 mol/L using differential pulse voltammetry. The proposed method was applied to the determination of chlorpromazine in urine sample, and the mean for standard addition recovery was 97%. In addition, the apparent diffusion coefficient of chlorpromazine was measured with different electrodes, the value follows such order as D（BMIMPF6/GC） 〉 D（1-octyl-3-methylimiazolium hexafluorophate （OMIMBF6/GC）） 〉 D（GC）.