摘要
AIM： To describe the trend in duodenal biopsy performance during routine upper gastrointestinal endoscopy in an adult Spanish population, and to analyze its value for the diagnosis of celiac disease in clinical practice. METHODS： A 15 year-trend （1990 to 2004） in duodenal biopsy performed when undertaking upper gastrointestinal endoscopy was studied. We analysed the prevalence of celiac disease in the overall group, and in the subgroups with anaemia and/or chronic diarrhoea. RESULTS： Duodenal biopsy was performed in 1033 of 13 678 upper gastrointestinal endoscopies （7.6%）; an increase in the use of such was observed over the study period （1.9% in 1990-1994, 5% in 1995-1999 and 12.8% in 2000-2004）. Celiac disease was diagnosed in 22 patients （2.2%）, this being more frequent in women than in men （3% and 1% respectively）. Fourteen out of 514 （2.7%） patients with anaemia, 12 out of 141 （8.5%） with chronic diarrhoea and 8 out of 42 （19%） with anaemia plus chronic diarrhoea had celiac disease. A classical clinical presentation was observed in 55% of the cases, 23% of the patients had associated dermatitis herpetiformis and 64% presented anaemia; 9% were diagnosed by familial screening and 5% by cryptogenetic hypertransaminasaemia. CONCLUSION： Duodenal biopsy undertaken during routine upper gastrointestinal endoscopy in adults, has been gradually incorporated into clinical practice, and is a useful tool for the diagnosis of celiac disease in high risk groups such as those with anaemia and/or chronic diarrhoea.
瞄准：在一张成年西班牙的人口在平淡的上面的胃肠的内视镜检查法期间在十二指肠的活体检视性能描述趋势，并且在临床的实践为乳糜泻的诊断分析它的值。方法：在当承担上面的胃肠的内视镜检查法时，执行的十二指肠的活体检视的 15 年趋势(1990 ～ 2004 ) 被学习。我们与贫血症或长期的腹泻在全面的组，并且在亚群分析了乳糜泻的流行。结果：十二指肠的活体检视在 13 678 上面的胃肠的内视镜检查法(7.6%) 中的 1033 个被执行；这的使用的增加在学习时期上被观察(1.9% 在 1990-1994， 5% 在 1995-1999 并且 12.8% 在 2000-2004 ) 。乳糜泻在 22 个病人(2.2%) 被诊断，这比在男人在女人是更经常的(3% 和 1% 分别地) 。十四从 514 (2.7%) 有贫血症的病人， 12 从 141 (8.5%) 与长期的腹泻并且 8 (19%) 从 42，与贫血症，正长期的腹泻有乳糜泻。一个古典临床的演讲在 55% 盒子中被观察， 23% 病人联系了疱疹样皮炎和 64% 介绍贫血症；9% 被家庭屏蔽诊断并且 5% 由秘密成员基因 hypertransaminasaemia。结论：在成年人在平淡的上面的胃肠的内视镜检查法期间承担的十二指肠的活体检视，逐渐地被合并了到临床的实践，并且是为在象有贫血症或长期的腹泻的那些那样的高风险组的乳糜泻的诊断的一个有用工具。
