Gastric cancer in a Caucasian population: Role of pepsinogen C genetic variants

AIM： To study the role of an insertion/deletion polymorphism in the pepsinogen C （PGC） gene, an effective marker for terminal differentiation of the stomach mucosa, in the susceptibility to the development of gastric lesions. METHODS： The study was performed with 99 samples of known gastric lesions and 127 samples without evidence of neoplastic disease. PCR was employed and the 6 polymorphic alleles were amplified： Allele 1 （510 bp）, Allele 2 （480 bp）, Allele 3/4 （450/460 bp）, Allele 5 （400 bp） and Allele 6 （310 bp）. RESULTS： Our results revealed that Allele 6 carriers seemed to have protection against the development of any gastric lesion （OR = 0.34; P 〈 0.001）, non-dysplastic lesions associated with gastric adenocarcinoma such as atrophy or intestinal metaplasia （OR = 0.28; P 〈 0.001） or invasive GC （OR = 0.39; P = 0.004）. CONCLUSION： Our study reveals that the Allele 6 carrier status has a protective role in the development of gastric lesions, probably due to its association with higher expression of PGC. Moreover, the frequency of Allele 6 carriers in the control group is far higher than that obtained in Asian populations, which might represent a genetic gap between Caucasian and Asian populations.

瞄准：在胃蛋白酶原 C (PGC ) 基因学习插入 / 删除多型性的角色，为胃粘膜的终端区别的一个有效标记，在到胃的损害的开发的危险性。方法：没有肿瘤的疾病的证据，学习与已知的胃的损害的 99 件样品和 127 件样品被执行。PCR 被采用， 6 多态的等位基因被放大：等位基因 1 (510 bp ) ，等位基因 2 (480 bp ) ，等位基因 3/4 (450/460 bp ) ，等位基因 5 (400 bp ) 并且等位基因 6 (310 bp ) 。结果：我们的结果表明等位基因 6 搬运人似乎对任何胃的损害的发展有保护(或 = 0.34；P<0.001 ) ，与象萎缩或肠的组织变形那样的胃的腺癌联系的 non-dysplastic 损害(或 = 0.28；P<0.001 ) 或侵略 GC (或 = 0.39；P = 0.004 ) 。结论：我们的学习表明等位基因 6 搬运人地位在胃的损害的发展有一个保护的角色，可能由于它有 PGC 的更高的表示的协会。而且，在控制组的等位基因 6 搬运人的频率比在亚洲人口获得了高是远的，它可能代表在白种人和亚洲人口之间的基因差距。