摘要
目的探讨子宫颈癌中环氧化酶-2(COX-2)与细胞核抗原Ki-67增生指数、促凋亡基因产物bax蛋白、微血管密度(MVD)以及CD44v6之间的关系,从而探讨COX-2参与子宫颈癌发生、发展的可能机制。方法采用组织芯片技术结合免疫组织化学PV法分别检测子宫颈癌中COX-2,Ki-67,bax,MVD(用CD34标记)和CD44v6的表达,并分析它们之间的关系。结果子宫颈癌中COX-2的表达分别与Ki-67标记指数(r=0.199,P=0.001)、MVD呈显著正相关(r=0.316,P<0.001),与CD44v6呈正相关(r=0.150,P=0.039);而COX-2的表达与bax的表达无直线相关关系(r=0.064,P=0.344)。结论COX-2参与子宫颈癌的机制可能与促进肿瘤血管形成、促进细胞增生及细胞黏附有关,与bax的表达无直接关系。
Objective To investigate the relationship between COX-2 and Ki-67 proliferation index, bax, microvascular density（MVD）and CD44v6 respectively. Methods The expression of COX-2,Ki-67, bax, MVD （labelled by CD34） and CD44v6 were examined by immunohistochemistry PV method and tissue chip method in 101 cases of cervical carcinomas epithelium. Results The expression of COX-2 in cervical carci- nomas has positive correlation with Ki-67, MVD and CD44v6, but has no correlation with bax. Conclusion The probable mechanisms are related with neovascularization, cell proliferation and cell adherence, but not related with the expression of bax.
出处
《肿瘤研究与临床》
CAS
2006年第11期742-745,共4页
Cancer Research and Clinic
