血管内皮生长因子表达与非小细胞肺癌侵袭、淋巴结转移的关系

Expressions of vascular endothelial growth factor in non-small cell lung cancer

目的探讨血管内皮生长因子(VEGF)表达与非小细胞肺癌(NSCLC)侵袭、淋巴结转移的相关关系。方法选取NSCLC组织58例及正常肺支气管黏膜组织25例,采用免疫组化染色法检测VEGF在各组织中的表达。结果58例肺癌组织VEGF阳性表达率为43.1%,明显高于正常肺支气管黏膜组织(14.3%)(P<0.01)。VEGF表达与NSCLC组织的分化程度、肿瘤组织类型无关,与淋巴结转移及生存期密切相关(P<0.05或P<0.01)。结论VEGF表达可能是NSCLC发生的一种生物学标志,VEGF的表达检测是判断NSCLC侵袭转移及预后的一个重要参考指标。

Objective To investigate the expressions of vascular endothelial growth factor（VEGF） in Non-Small Cell Lung Cancer （NSCLC）and its relationship to histopathological features. Methods The expressions of VEGF was observed by immunohistochemical methods in 58 cases of non-small cell lung cancer and 25 cases of non-lung cancer tissue. Results The positive rates of VEGF in NSCLC were 43.1% which was significantly higher than those in non-lung cancer tissue（14.3 %, P 〈0.01）. The expressions of VEGF have no significant relationship with pathological grade and histological types. The expressions of VEGF was related to lymph nodes metastasis and survival time （P 〈0.05 or P 〈0.01）. Conclusion VEGF over expression may be a biological marker in non-small cell lung cancer, and it may serve as a significant marker for predicting the metastasis and the prognosis of non-small cell cancer patients.