体外反搏的过去现在与将来(英文)

The Past,Present and Future of External Counterpulsation

体外反搏技术于1976年首先在我院创立。上世纪90年代之前,体外反搏作用机制主要定位在提高动脉舒张压,促进侧枝循环建立,进而改善器官组织的缺血状态。近年来经过大量的基础研究和临床观察证实,体外反搏在增加器官组织血流灌注的同时,还通过促进动脉血流加速,提高血流切应力,从而具有保护血管内膜,促进损伤血管内皮细胞的结构与功能修复,从而抑制动脉粥样硬化的发生与进展。这些作用被认为与体外反搏促进了血管内皮相关基因的表达与调控有关。基于上述基础理论的最新研究成果,我们研制成功了更有效地提高血流切应力,更适宜于保护血管内膜功能的新一代体外反搏装置。

Enhanced external counterpulsation（EECP） was developed in our laboratory and applied in clinical setting since 1976. Before the year of 1990, the mechanism of this treatment was supposed to promoting collateral circulation by increasing diastolic pressure during counterpulsation. According to a series of investigations, we discovered and confirmed that the flow shear stress were increased obviously during EECP, regulating a series of reaction of shear stress responsive elements, inducing vascular endothelial cell （VEC） repair mechanism, improving VEC function, all of which contribute to the inhibition of development of atherosclerosis. A new generation of EECP device was designed based on the advances above and aimed at promoting the aterial flow shear stress more effectively in turn to protect vascular endothelium.