米非司酮联合氨甲蝶呤治疗异位妊娠临床观察

The Application of Mifepristone Together with Methorexate in Treatment of Ectopic Pregnancy

目的以氨甲蝶呤(MTX)为对照,观察米非司酮联合氨甲蝶呤保守治疗异位妊娠的作用。将68例患者随机分为两组,以氨甲蝶呤(MTX)为对照,观察米非司酮联合氨甲蝶呤的治疗效果。结果2组均于治疗后一周人绒毛促性腺激素开始明显下降,治疗两周包块缩小或不增大,与治疗前比较差异显著(P<0.05)。联合治疗组与氨甲蝶呤单独组成功率为94.1%和76.5%,两者较有显著差异。结论米非司酮联合氨甲蝶呤治疗异位妊娠效果优于单用氨甲蝶呤,无明显毒副反应,成功率高,对于未生育妇女避免手术风险,减少并发症有一定的临床意义。

Objective To explore the efficacy of mifepriston and methorexate for conservative treatment of extopic pregnancy compared with methorexate. Methods Sixty-eight cases were divided into group A and B by random. Group A was treated with mifepristone and methorexate . group Bwith methorexate, Results The serum β-hcG of two groups was declined remarkably after a week of treatment （P〈 0.05）. Mass diameter was decreased. Remarkably or not increased after 2 weeks of treatment （P〈0. 05）. Cure rate of group A and Bwere 94.1 and 76.5 respectively （P〈0.05）.Conclusion, The effect with mifepristone and methorexate is better than with methorexate in treating treating ectopic pregnancy . There is no obvious povisonous effect and a high care rate. It is significant and applicable for conserrative treatment of ectopic pregnancy especially for those unpregancy women.