老年终末期肿瘤患者血浆脑利钠肽前体水平变化及其临床意义

Change of plasmic pro-BNP level and its clinical significance in presby-tumor patients

目的探讨老年肿瘤患者血浆脑利钠肽前体(pro-BNP)水平的变化及其临床意义。方法选取36例肿瘤患者为实验组,另选取同期住院非肿瘤患者20例为对照组。分别于入院第1天和第14天对患者心功能分级、检测2组患者血浆pro-BNP浓度及左心室射血分数(LVEF),分别观察2个时间点各指标间的差异。结果入院第1天肿瘤组患者心功能评分、LVEF与对照组差异无统计学意义,入院第14天肿瘤组患者心功能、LVEF显著低于对照组,差异有统计学意义(P<0.05);入院第1天和第14天肿瘤组患者血浆pro-BNP浓度均显著高于对照组,差异有统计学意义(P<0.01)。结论血浆pro-BNP水平能较准确地反映老年肿瘤患者左室功能状态,其敏感性高于超声心动图,对老年住院患者心力衰竭的风险评估具有早期应用价值。

Objective To investigate the change of plasmic pro-BNP level and its clinical significance in presby-tumor patients. Methods Forty patients were divided into the tumor group and control group, At 1d and 14d after hospitalization, the class of heart function was decided and the LVEF was checked, individually. Results At ld after hospitalization, there were no apparent differences about the score of heart function and LVEF between the two groups. But at 14d, the score of heart function and LVEF in the tumor group was significantly lower than that in control group （P〈0. 01）. On the other hand, the plasmic pro-BNP in the tumor the group was significantly higher than that in the control group at both the two time sites（P〈0. 01）. Conclusion The plasmic pro-BNP level can reflect the left ventricle function of presby-tumor patients to some extent and its sensibility is higher than UCG and can be used as a risk assessment tool for estimating the presby-tumor patients＇ risk of having a heart failure at the early stage.