雷贝拉唑、克拉霉素、阿莫西林治疗Hp阳性十二指肠溃疡的疗效观察

Trigeminal Therapy with Rabeprazol,Clarithromycin and Amoxicillin for Eradicationof Helicobacerpylori Infection in Duodenal Ulcer Patients

目的观察雷贝拉唑、克拉霉素、阿莫西林短程三联疗法对幽门螺杆菌(Hp)阳性的十二指肠溃疡的治疗效果及副作用。方法将105例伴有Hp感染的十二指肠溃疡患者随机分两组,A组52例,给予雷贝拉唑10mg、克拉霉素500mg,阿莫西林1000mg,每天2次口服,疗程7天(A组);B组53例,给予雷尼替丁150mg、阿莫西林1000mg,每天2次口服,甲硝唑200mg,每天3次口服,疗程7天(B组)。疗程结束1个月后复查胃镜,检查Hp。结果A组Hp根除率92.3%、活动期溃疡愈合率94.2%、症状缓解率为100%,不良反应的发生率为3.8%。而B组上述指标则分别为73.6%、75.5%、77.4%、17.0%;两组比较均具有统计学差异。结论雷贝拉唑、克拉霉素、阿莫西林短程三联疗法对幽门螺杆菌(Hp)阳性的十二指肠溃疡的治疗具有良好的效果,且副作用少。

Objective To determine the short-trigeminal therapy with arteriole, clarithromycin and amoxieillin in eradication of Helicobacter pylori（Hp） infection in duodenal ulcer patients to observe the by-effects of this therapy. Methods 105 patients with Hp-assoclated duodenal ulcer were divided into two groups by random. Patients in group A（52 cases） were treated with trigeminal therapy with arteriole 10mg bid,clarithromycin 500mg bid and amoxicillin 1000 mg bid for one week. （Group A）. Patients in group B（53cases） were treated with trigemlnal therapy with ranitidine 150 mg bid,amoxicillin 1000 mg bid and metronidazole 200mg tid for one week. （Group B）. One month after anti- Hp therapy endoscopy and examination of Hp were repeated. Results The eradication rate of Hp,symptomatic relief rate,healing rate and the untowrrd reaction rate of active ulcer in group A were 92.3% ,94.2%, 100%, and 3.8%. Respective index in group B were 73. 6%/oo, 75.5%, 77.4%, 17.0%. There was significant difference between group A and group B. Conclusions The short-trigeminal therapy with arteriole,clarithromycin and amoxicillin in eradication of Hp infection is highly effective and has less side effects.