共轭亚油酸免疫学研究进展

Research Progress on Immunology of Conjugate Linoleic Acid

CLA是一类含十八碳二烯酸次生衍生的共轭多烯的多种位置与空间异构体的总称,仅“c9,t11”、“t10,c12”、“t9,t11”、“t10,t12”异构体具有较强的生物学功能。免疫学方面已研究表明:能够增加外周血液和肠系膜淋巴结中的IgGI、gA和IgM的含量,降低IgE的水平;增加促有丝分裂原和促进T、B淋巴细胞增殖调控;提高T细胞CD+特异效应物的功能和淋巴细胞的细胞毒性;以及激活巨噬细胞表达iNOS-mRNA、IL-1I、L-6I、L-4和TNF-α等细胞因子能力等的参与对机体免疫系统的调节作用。这些缓解动物免疫应激功能表达的调控机理,可能与激活巨噬细胞核转录因子———过氧化物酶增殖体激活受体-γ(PPAR-γ)的反应元件,降低干扰素γ诱导的炎性介质mRNA表达有关。

The conjugate linoleic acid is one kind conjugate polyene which including many kinds of the spatial and positions isomer that always derivation from the vaccenic acid, only the isomer such as＂c9, t11＂, ＂t10,c12＂, ＂tg, t11＂and ＂t10, t12＂ has the strong biology function. The aspect of the immunology research indicated that, they can increase the content of IgG, IgA and IgM and reduces the IgE level in the circumference blood and mesentery lymphatic node; Increases the mitosis original, promotes the T and B lymphocyte multiplication regulation; Enhances the function which T-cell CD^＋ special effect knows how to deal with and lymphocyte cell toxicity; The activation macrophage expresses abilities of the cell factor including iNOS-mRNA, IL-1, IL-6, IL-4 and TNF-α, and then participates in organism immune system control action. The regulative mechanism can alleviate the expression of animal immunity stress function, it is possible concerned with activation macrophage nucleus duplication factor-the response element of peroxidase proliferation activation receptor - gamma （PPAR-γ）, reduces the mRNA expression which induced the inflammatory medium by γ-interferon.