甘草次酸钠口服给药的抗炎及免疫调节作用

Antiinflammatory and immune regulating effect of sodium glycyrrhetinic acid by oral administration in mice and rats

ＳＧＡ多次灌胃使巴豆油诱发的小鼠耳肿减轻，并抑制佐剂性关节炎大鼠炎足肿胀、滑膜增生、血管翳形成及关节软骨破坏；使正常小鼠Ｔ淋巴细胞比率升高，但使佐剂性关节炎大鼠异常升高的Ｔ淋巴细胞比率降低，呈现双向免疫调节作用。

The antiinflammatory and immune regulating effect of sodium glycyrrhetinic acid (SGA) was studied by oral administration in mice and rats. The results showed that croton oil induced mouse ear edema was not affected by a single dose but inhibited by repeated administration of SGA. Repeated treatment with SGA significantly inhibited paw edema of rats with ajuvant arthritis (AA), reduced proliferation of synovial cells and pannus formation, and eliminated the destruction of articular cartilage in inflammed joints of AA rat. Meanwhile, T lymphocyte ratio was increased in normal mice and decreased in rats with ajuvant arthritis by SGA, suggesting that SGA possesses two way regulating activity for immune function.