摘要
目的确定解脲脲原体（Ｕｕ）与新生儿肺炎等感染的关系。方法用间接血凝试验（ＩＨＡ）检测妊娠晚期孕妇血清Ｕｕ抗体，并对胎盘做Ｕｕ分离培养，用酶联免疫吸附试验（ＥＬＩＳＡ）检测部分胎儿脐血清Ｕｕ－ＩｇＭ抗体。并对孕妇血清Ｕｕ抗体阳性组和阴性组新生儿感染情况进行比较。结果１６０名孕妇血清中，８１例Ｕｕ抗体阳性，从其中１３例的胎盘中分离培养出Ｕｕ。用ＥＬＩＳＡ法检测５例胎盘Ｕｕ阳性的新生儿脐血Ｕｕ－ＩｇＭ，３例阳性。孕妇血清抗体阳性组的新生儿肺炎１６例，发热者１０例，两者总发病率为５４．５％，较阴性组高（３７．９％，Ｕ检验Ｐ＜０．０５）。结论Ｕｕ是引起新生儿感染。
ObjectiveToascertaintherelationbetweenneonatalinfectionandUreaplasmaure-alyticum(Uu),westudied160normalhealthypregnantwomenandtheirneonates.MethodsSerumspecimensfrompregnantwomenwerecolectedbeforedelivery,andsenttoourlabforserologicaltests.Indirecthemagglutinatingantibody(HA)wasdeterminedbyusingsensitivesheepredcelofUuantigen.Uu-IgMincordbloodfromsomeneonateswastestedbyELISA.ResultsOfthe160pregnantwomen,81hadelevatedlevelsofUuantibody.Therewasahighermorbility(54.5%)a-mongneonateswithneonatalinfectionwhosemothershadelevatedlevelsofureaplasmaantibody.16neonateshadpneumoniaand10neonateshadfeverwithoutreason.Inthecontrolswithoutelevatedlevelstoureaplasmaantibody,themobilityamongtheirneonateswas37.9%.Therewasasignifi-cantdiference(P<0.05)betweenthetwogroup.ConclusionThesedataindicatethatureaplasmaurealyticummaybeanimportantpathogeneinneonatalinfection,especialyinneonatalpneumonia.
基金
国家自然科学基金
关键词
解脲脲原体
新生儿
感染
UreaplasmaurealyticumInfant,newbornOmfectopm
