兰坪县地方性克汀病补碘5年后碘代谢及甲状腺功能研究

The Study on Iodine Metabolism and Thyroid Function of Endemic Cretinism after 5-year-iodine Suppl ement in Nanpin County

对兰坪县箐门碘缺乏病区补碘５ａ后神经型地克病人进行碘代谢及甲状腺功能研究。结果：尿碘基本不低；摄￣（１３１）Ｉ率均值正常，无碘饥饿病例；血清ＴＴ＿４，ＴＴ＿３，ＦＴ＿４，ＦＴ＿３，ｒＴ＿３，ＴＳＨ均值正常，但与非病区组相比，ＦＴ＿３较高、ｒＴ＿３较低（Ｐ＜０．０１）；甲状腺功能绝大多数正常或代偿，２．６３％失代偿和３．９５％激素性甲亢，结果表明，箐门１／５万碘盐防治效果较好，少数甲功不正常反映补碘效应存在明显的个体差异。ＦＴ＿３，ＦＴ＿４与ＴＳＨ联合判断甲功异常比ＴＴ＿３，ＴＴ＿４及ＴＳＨ联合敏感。

Iodine metabolism and thyroid function were explored among 76 cases of neuro一cretinism after 5 years of iodine salt(1:50000)supplement at Qinmen district of Nanpincounty,The results were shown as follows:the urine iodine was basically not low;the averageintake value of￣(131)I was normal,without any I一hunger cases;the average serum value was nor-mal for TT_4,TT_3,FT_4,FT_3,rT_3,and TSH,but with FT_3 being higher and rT_3 being lowerthan those of the control group in non一IDD region(P<0.01);the thyroid function was mostlynormal or compensatory,with 2.63%of broken compensation and 3.95%of hormonal hyper-thyroidism. All the above suggested t hat 1/5 0000一salt therapy was effective in Qinmen dis-trict,that significant individual difference still existed in the I一supplememt effect,as reflected inafew cases of thyroid dysfunction, and that FT_3一FT_4一TSH joint test was more sensitive thanFT_3一FT_4一TSH one in the diagnosis of thyroid dysfunction.