甲壳质选择性降解和葡糖胺衍生物的合成

STUDIES ON THE SELECTIVE DEGRADATION OF CHITIN AND THE SYNTHESIS OF THE DERIVATIVES OF GLUCOSAMINE

研究甲壳质的降解反应，获得了葡糖胺（１）、壳二糖（２）、壳三糖（３）和壳四糖（４）的乙酰化产物以安为原料。用混酐法或ＤＣＣ法合成了６个新人合物，Ｎ－（Ｎ－叔丁氧甲酰基－Ｌ－脯氨酰基－Ｄ－葡俯胺－５），Ｎ－苯甲酰基－０－四乙酰基－Ｄ－葡糖胺（６）、Ｎ－乙酰水杨基－０－甲酬谢锘－Ｄ－葡糖胺（７）、Ｎ－－（Ｎ－邻苯二甲酰－Ｌ－Ｌ亮氨酰基）－８－四乙酰基－Ｄ－Ｄ葡糖胺（８）。

The hydrolysis and acetolysis of chitin gave glucosamine, pentacetyl-glucosamine (1), octa-acetyldiglucosamine (2), undecaacetyl-triglucosamine (3), and te-tradecaacetyl tetraglucosamine (4). Six glucosaminic derivatives; N-(N'-Boc-l-propyl)-O-tetraacetylglucosamine (7), N-(N'-phthaloyl-L-leucyl)-O-tetraacetyl-D-glucosamine (8). N-( N'-phthaloyl-L-valyl )-O-tetraacetyI-D-glucosamine (9), N-( N'-phthaloyl-L-phenyalanyl )-O-tetraacetyl-D-glucosamine (10), N-benzoxyl-O-tetraacetyl-D-glucosamine (5) and N-aceylsallcyl-O-tetraacetyl-D-glucosamine (6) were synthesized.