CD_（44）在肺癌中的表达与组织学类型及淋巴结转移的关系

Expression of CD_(44) in different histological types of lung cancer and its significance in lymphnode metastasis

采用免疫组化方法（ＬＳＡＢ法）检测ＣＤ＿（４４）在６５例肺癌组织中各组织学类型的表达，并探讨组织学类型与淋巴结转移的相关性。结果显示：非小细胞肺癌阳性率为７１．７％（３８／５３例），１２例小细胞肺癌中仅２例阳性。ＣＤ＿（４４）的表达在非小细胞肺癌中１６例鳞癌有７例阳性，１７例腺癌有１５例阳性，１５例腺鳞癌有１例阳性，５例大细胞癌均阳性。经卡方检验Ｆｉｓｈｅｉ精确概率法分析，小细胞癌与腺癌、腺鳞癌、大细胞癌之间和鳞癌与腺癌、大细胞癌之间均有显著性差异（Ｐ＜０．０５～０．００１）．非小细胞肺癌伴肺门淋巴结转移者，ＣＤ＿（４４）的阳性表达分别为６例鳞癌均阳性，４例大细胞癌中３例阳性，１４例腺鳞癌场中６例阳性，１０例腺癌中３例阳性。其中鳞癌和大细胞癌与肺门淋巴结转移有密切的相关性。结果提示：ＣＤ＿（４４）可作为区分肺癌组织学类型及肺门淋巴结转移潜能的新的辅助标志。

In order to study the expression of CD_(44) in different histological types of human lung cancer andthe relationship between the expression of CD_(44) and lymph node metastasis, 65 cases of human lung carcino-mas were investigated to detect the expression of CD_(44) by immunohistochemistry(LSAB method).The re-sults showed that the positive percentage was 71.7%(38/53) in non-small cell lung carcinomas(NSCLCs). Only 2 of 12 cases in small cell lung carcinomas (SCLCs) showed CD_(44) positive expression. The positive rateof NSCLCs were 7 of 16 cases in squamous cell carcinomas (SCC),15 of 7 cases in adenocarcinomas(AC),11 of 15 cases in adenosquamous carcinomas (ASC)and all five cases in large cell carcinomas(LCC).There were significant differences (P<0.05￣0.001)between SCLC and AC,SCLC and ASC,SCLC andLCC,SCC and AC,and SCC and LCC, The NSCLCs were thought to be able to be used to match the ex-pression of CD44 with lymph node metastasis predilection. Lymphnode metastasis in CD44 positive expres-sion cases occured in all six cases in SCC,3 of 4 cases in LCC,6 of 16 cases in ASC,3 of 10 cases in AC.There were significant differences(P<0.05)between SCC and AC,and SCC and ASC. The fact that ex-pression of CD44in cancer cell can be used to discriminate among the histological types and to evaluate themetastatic predilection made CD_(44) a valuable new marker for lung carcinomas.