HLA相容性对异基因造血干细胞移植疗效影响

Effect of HLA-compatibility on allogeneic bone marrow transplants inchildren

采用补体依赖微量淋巴细胞毒方法观察了ＨＬＡ相容性对异基因造血干细胞移植疗效的影响，结果初步表明：供受者之间ＨＬＡ相容程度与异基因骨髓移植存活率、排斥率、ＧＶＨＤ发生率及严重程度有明显的相关性。

In this study, HLA-typing in l3 patients receiving a partially matched HSCT was performed bythe standard microlymphocytotoxicity technique. Effect of HLA-compatibility between donor and recipienton allogeneic BMT in children was analysed. The primary results showed that graft rejection GVHD occur-rence and severity were correlated strongly with the degree of HLA-disparity between donor and recipientin HLA-identical sibling HSCT or l antigen mismatched sibling HSCT,GVHD incidence and severty werelower than those in 2 or 3 antigen mismatched family donor HSCT. In transplants ntilizing donors present-ing 2 or 3 HLA loci disparity with recipient,severe(grade Ⅲ-Ⅳ)acute GVHD which can not be controlledeasily would occure with significantly lower survival probability.