摘要
背景与目的：探讨脱氢表雄酮（dehydroepiandrosterone，DHEA）的发育毒性。材料与方法：将SD孕鼠随机分为5组，每组16只，分别为阳性对照组（阿司匹林300mg／kg），阴性对照组（蒸馏水）和DHEA10．4、20．8、41．7mg／kg3个剂量组，在受孕第7～16d连续10d给大鼠灌胃DHEA，第20d解剖取出胎鼠，观察DHEA对母体及胎鼠的影响。结果：DHEA剂量在10．4mg／kg时导致孕鼠流产；20．8、41．7mg／kg时孕鼠、胎鼠体重增加减缓，胸骨发育迟缓；41．7mg／kg时，胎鼠内脏畸形增加。3个剂量组胎鼠活胎率均降低。结论：DHEA对孕鼠及胎鼠均有毒性表现。
BACKGROUND ＆ AIM： To detect maternal and fetal toxicity of dehydroepiandrosterone（DHEA） MATERIALS AND METHODS： SD pregnant female rats were divided randomly into 5 groups, 16 rats in each group.The rats in positive control group received aspirin 300 mg/ kg and distilled water was given to rats as the negative control group.Three DHEA groups were treated with 10.4,20.8 and 41.7 mg/kg.The rats were given DHEA from 7 d to 16 d of pregnant continuously for 10 days, and were sacrificed on 20th d of pregnancy. Adverse effects on pregnant rats and fetuses were assessed. RESULTS： DHEA at 10.4 mg/kg caused miscarriages in pregnant rats, 20.8 and 41.7 rng/ kg slowed down the weight increase of mother and fetuses, and slowed sternum growth. At 41.7 mg/kg visceral abnormality in fetuses increased.All three concentrations of DHEA decreased the number of living fetuses. CONCLUSION： DHEA had adverse effects in both pregnant rats and fetuses.
出处
《癌变．畸变．突变》
CAS
CSCD
2006年第6期479-481,共3页
Carcinogenesis,Teratogenesis & Mutagenesis
关键词
脱氢表雄酮
生殖毒性
致畸
流产
大鼠
DHEA
reproductive toxicity
teratogenesis
miscarriage
rat
