胰腺癌中细胞外基质金属蛋白酶诱导剂的表达及临床意义

Significance of expression of extracellular matrix metalloproteinase inducer in pancreatic cancer

目的检测细胞外基质金属蛋白酶诱导剂(EMMPRIN)在胰腺癌中的表达及其与P-糖蛋白(P-gp)、血管内皮生长因子(VEGF)的关系,以探讨胰腺癌细胞多药耐药和浸润转移是否有关联。方法应用免疫组化SP法检测34例胰腺癌患者癌组织中EMMPRIN、P-gp和VEGF的表达,用卡方检验和相关分析了解其与临床病理参数的关系。结果EMMPRIN、P-gp和VEGF在胰腺癌组织中阳性表达率分别为61．8％、55．9％和64．7％。EMMPRIN、P-gp、VEGF阳性表达与性别、年龄、肿瘤大小及病理分化程度无关(P＞0．05),但与淋巴结转移有关(P＜0．05)。EMMPRIN表达与P-gp、VEGF分别相关(r=0．398和r=0．432,P＜0．05)。结论胰腺癌中EMMPRIN与P-gp、VEGF表达有关,提示肿瘤耐药、浸润和转移之间有一定相关性,EMMPRIN可能是其中的关键因子。

Objective To investigate the expression of extracellular matrix metalloproteinase inducer （EMMPRIN） in pancreatic cancer and its relationship with P-glycoprotein （P-gp） and vascular endothelial growth factor （VEGF）, and to study its correlation with invasion, metastasis and drug resistance. Methods The expressions of EMMPRIN, P-gp and VEGF in 34 cases of pancreatic cancer were detected by immunohistochemistry. The correlation analysis and Chi-squared test were been used by SPSS 10. 0. Results The positive rates of EMMPRIN, P-gp and VEGF in pancreatic cancer were 61.8%, 55. 9% and 64. 7% respectively. EMMPRIN, P-gp and VEGF were associated with lymph node metastasis （P〈0.05）, but not associated with sex, age, size of tumor and degree of differentiation （P〉0.05）. There were close relationship between EMMPRIN and P-gp, VEGF respectively （r=0. 398, r = 0.432,P〈0.05）. Conelusions EMMPRIN, P-gp and VEGF were higher expressed in pancreatic cancer. EMMPRIN express was correlated with both P-gp and VEGF. It has indicated that during the progression of pancreatic cancer, there are close relationship between invasion, metastasis and drug resistance, and EMMPRIN may play key role in this process.