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不同乳腺疾病中ERK、PI3-K mRNA的表达 被引量：1

Expression of ERK and PI3-K mRNA in various breast dieases and its significance
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摘要 目的:检测正常乳腺组织、良性增生、非典型增生和乳腺癌中ERK、PI3-KmRNA的表达,探讨其在乳腺癌发生、发展中的作用及关系。方法:应用RT-PCR方法检测ERK、PI3-KmRNA在正常乳腺组织及不同乳腺疾病中的表达。结果:ERK2和PI3-KmRNA在乳腺癌组织中表达明显高于其他乳腺组织,分别为100%(37/37)和94.59%(35/37)。ERK2mRNA在乳腺癌、非典型增生、良性增生和正常组织的表达强度依次减弱;PI3-KmRNA表达在乳腺癌中明显增高,而在非典型增生和良性增生和正常组织中的表达无明显差别。结论:MAPK/ERK途径参与乳腺癌发生的信号转导,而PI3-K途径参与乳腺癌后期进展阶段的信号转导。 Objective： To investigate the expression and significance of ERK and PI3 - K mRNA in various breast lesions and breast carcinoma. Methods ： RT - PCR was used to detect the expressions of ERK and PI3 - K mRNA in 37 cases of breast cancer,6 cases of atypical hyperplasia and 15 cases of benigh breast diseases. Results： The rates of positive expression of ERK and PI3 - K in breast cancer were 100% （ 37/37 ） and 94.59% （ 35/37 ） respectively and higher than other tissues. The tendency of decreased expression of ERK mRNA was breast cancer, atypical hyperplasia, benigh diseases and normal tissue. The difference of the levels of expression of PI3 - K mRNA in atypical hyperplasia and benigh diseases was not significant. Conclusion ： ERK and PI3 - K pathways are involved in breast carcinogensis.
作者 马萍 宋敏 张英
机构地区 中国医科大学附属第一医院肿瘤研究所 中国医科大学基础医学院病理教研室
出处 《现代肿瘤医学》 CAS 2006年第12期1528-1530,共3页 Journal of Modern Oncology
基金 辽宁省教育厅高等学校科研项目基金(编号:2004D107)
关键词 乳腺疾病 信号转导 MAPK PI3-K ERK breast lesions signal transduction ERK PI3- K
分类号 R735.2 [医药卫生—肿瘤]
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参考文献8

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共引文献14

同被引文献7

  • 1杨竹林,邓星辉,杨乐平,苗雄鹰,刘栋才.胰腺癌组织化学趋化因子表达与肿瘤相关巨噬细胞计数的相关性[J].世界华人消化杂志,2004,12(10):2349-2352. 被引量：4
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现代肿瘤医学
2006年 第12期

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