微波辐射下催化合成氯乙酸正戊酯的研究

Catalytic synthesis of n-amyl chloroacetate under microwave irradiation

在微波辐射下,以固体超强酸A lC l3.CuSO4为催化剂合成氯乙酸正戊酯。最佳反应条件为:氯乙酸和正戊醇的物质的量比为1∶2.0,催化剂用量为1.50 g无水硫酸铜和1.25 g无水三氯化铝的混合物,微波输出功率为522 W,反应时间为16 m in。在此反应条件下,氯乙酸的酯化率为96.1%。

The synthesis conditions of amyl chloroacetate are studied in the presence of solid superacid AlCl3·CuSO4 as catalyst under microwave irradiation. The best conditions are as follows：the mole ratio of chloroacetic acid to n-pentanol is 1 ： 2.0, the amount of catalyst is the complex of copper（Ⅱ） sulfate anhydrous 1.5 g and aluminum chloride anhydrous 1. 25 g ,irradiation power 522 W,reaction time 16 min. Under above conditions,the esterification rate of chloroacetic acid is 96.1%.