（＋）－布雷菲德菌素A的中间体合成研究Ⅲ．α、β－不饱和酯的合成

Studies on synthesis of intermediates of (+) brefeldin A III. synthesis of α,β unsaturated ester

（＋）－布雷菲德菌素Ａ的重要中间体——α、β－不饱和酯（８）可以（１Ｒ，２Ｒ，２′Ｒ）－１－（１′－二甲叔丁硅氧基－２′－羟基乙基）－２－氰基环戊烷（７）为原料，经氧化和Ｗａｄｗｏｒｔｈ－Ｅｍｍｏｎｓ反应制得。

α,β unsaturated ester(8), a valuable intermediate for (+) brefeldin A, was synthesized from (1 R , 2 R , 1′ R ) 2 cyano 1 (1′ dimethyl t butylsilyloxy 2′ hydrox yethyl) cyclopentane(7) by oxidation and Wodworth Emmons reaction.