20(R)-人参皂苷Rh_2抗B_(16)-BL6黑色素瘤转移的作用

Inhibitory Effect of 20(R)-ginsenoside Rh_2 on B_(16) Melanoma Metastasis

目的:探讨20(R)人参皂苷Rh2抗B16-BL6黑色素瘤转移的作用及其机制。方法:采用B16黑色素自发转移模型观察Rh2对B16黑色素瘤转移的作用,观察Rh2对B16黑色素瘤细胞自身侵袭能力的影响。结果:在B16黑色素瘤自发肺转移的实验中,Rh2组C57BL/6N小鼠肺部转移结节数明显减少,Rh2作用后的B16黑色素瘤细胞侵袭人工基底膜能力明显下降。结论:Rh2可明显抑制B16黑色素瘤的肺转移,该作用可能与降低B16黑色素瘤细胞的侵袭能力有关。

Objective ：To study the inhibitory effect of 20（R） -ginsenoside Rh2 on B16 - BL16 melanoma metastasis and its mechanism. Methods ：The spontaneous models of B16 melanoma were used to investigate the inhibitory effects on tumor metastasis. And the effect of Rh2 on invasive ability of B16 cells was observed in vitro. Results ：In the spontaneous and experimental lung metastasis models of B16 melanoma,the number of tumor colonies in lung in each Rh2 group was lower than that in the control group. The number of vessels oriented toward the tumor mass and the invasive ability of B16 cells decreased obviously after treated with Rh2. Conclusion ：20 （R） - ginsenoside Rh2 can obviously inhibit the lung metastasis of B16 melanoma. The inhibitory effect partially dues to its inhibiting the lung metastasis of B16 melanom. The inhibitory effect partially dues to its inhibiting angiogenesis induced by B16 melanom and decreasing the invasive ability of B16 cells.