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局灶性脑缺血再灌注损伤后大脑皮层信号转导和转录激活因子3表达的变化 被引量：2

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摘要 目的研究脑缺血再灌注损伤后大脑皮层信号转导和转录激活因子3(STAT_3)的表达。方法采用雄性Wistar大鼠建立局灶性缺血再灌注模型,运用RT-PCR方法检测脑缺血再灌注损伤后12、24、72h大脑皮层STAT_3的表达变化。结果假手术各组与正常组之间STAT_3的比较无统计学差异(P>0.05);缺血再灌注12h组与72h组之间STAT_3的比较无统计学差异(P>0.05);其余任意两组之间STAT_3值的比较,差异均有统计学意义(P<0.01)。结论缺血1h再灌注损伤后STAT_3在大脑皮层表达均增强,且在12h开始有STAT3表达增加,24h表达达高峰,72h表达已开始减少。
作者 聂莹雪 吴晓黎 郭玫
机构地区 中国医科大学附属第一临床医院神经内科 中国医科大学附属第二临床医院神经内科 沈阳医学院沈洲医院神经内科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2006年第11期1522-1524,共3页 Chinese Journal of Gerontology
关键词 脑缺血再灌注 信号转导 STAT3
分类号 R743.3 [医药卫生—神经病学与精神病学]
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参考文献12

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共引文献9

同被引文献25

  • 1郭云良,王岭,高晓玉,张美增,孙成云.脑缺血再灌注损伤后神经细胞增殖相关因子基因的表达[J].解剖学杂志,2005,28(5):538-541. 被引量：5
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中国老年学杂志
2006年 第11期

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