内皮抑素在宫颈癌组织中表达的研究

A Study on the Expression of Endostatin in Cervical Cancer

目的探讨内皮抑素在宫颈癌组织中的表达及与病理分化、临床分期和盆腔淋巴结转移的关系。方法用免疫组化S-P法检测52例宫颈癌和14例正常宫颈组织内皮抑素的表达。结果内皮抑素在宫颈癌组织阳性表达率为(70.0±21.23)%,在正常宫颈组织为(21.43±3.18)%,两者差异有统计学意义(P<0.05);内皮抑素阳性表达率与宫颈癌细胞病理分化、临床分期和盆腔淋巴结转移有密切关系。结论内皮抑素在宫颈癌生长、侵袭和转移过程中起重要作用。

Objective To investigate the expression of endostatin, and the relationship among the histological grading, clinical stage and pelvic lymph node metastasis in cervical cancer. Methods The expression of endostatin in 52 cases with cervical cancers and 14 normal cervix tissues were detected by immunohistochemicaI assay. Results The positive rate of endostatin in cervical cancers was （70.0 ± 21.23） %, While （21.43 ± 3.18） % in normal cervix tissues, the difference between them was significant（ P 〈 0.05 ）. The positive rate of endostatin was closely related to the histological grading, clinical stage and pelvic lymph node metastasis of cervical cancers. Conclusions Endostatin may play an important role in the growth, infiltrating development and metastasis of cervical cancers.