狂犬病发病机理的研究进展

The Research Advance of Rabies Pathogenesis

狂犬病是由狂犬病病毒引起的一种重要的人兽共患传染病,在人主要表现为急性、几乎不可逆转的脑脊髓炎,目前没有有效的治疗方法,病死率几乎100%。目前对狂犬病病毒感染和狂犬病发病机理的认识还很不透彻,但近年来的研究也取得了不少进展,主要涉及狂犬病病毒受体、神经细胞功能失调的原因和神经细胞凋亡机制、狂犬病病毒与机体免疫系统相互作用机制,狂暴型和麻痹型狂犬病的发病机制,这些都将为狂犬病的治疗研究起到推动作用。

Rabies is normally a rapidly fatal neurological disease and to date therapeutic efforts in humans have proved fu. tile, case fatality rate nearly 100%.There are still many unanswered questions in the pathogenesis of rabies, but recent progress has been made, including rabies virus receptors, neuronal apoptosis and dysfunction, interactions of rabies virus and the immune system, mechanisms for the two clinical forms of rabiest encephalitic and paralytic .Hopefully, advances in our understanding of rabies pathoganesis will lead to advances in the treatment of this dreaded disease.