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胰高血糖素样肽2(GLP-2)与肠道保护 被引量：1

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摘要 胰高血糖素样肽2(Glucagon-likepeptide2,GLP-2)由小肠和大肠的内分泌细胞产生并分泌,GLP-2在循环中二酰肽肽酶IV的作用下氨基末段迅速裂解失去活性,并通过肾脏代谢掉。GLP-2具有促进肠黏膜生长发育、肠上皮隐窝细胞增殖,抑制肠黏膜上皮细胞和隐窝细胞的凋亡,引起小肠绒毛增高、肠重量增加的作用;GLP-2还具有调节肠道刷状缘酶活性,保持小肠粘膜上皮的完整性,促进小肠损伤后的修复等作用,因此,GLP-2在动物营养上的应用前景广阔。
作者 鲍淑青 陈海军 张克英
机构地区 四川农业大学动物营养研究所 四川农业大学动物科技学院禽病中心
出处 《饲料工业》 2006年第23期16-18,共3页 Feed Industry
关键词 GLP-2 肠道保护 动物营养 综述
分类号 S821.5 [农业科学—畜牧学]
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参考文献19

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同被引文献16

  • 1陈吉,吴国豪.胰高血糖素样肽2与肠道保护[J].中华胃肠外科杂志,2005,8(6):548-550. 被引量：2
  • 2王丽娜,陈杰,赵茹茜.胰高血糖素样肽-2及其受体与胃肠道的发育[J].畜牧与兽医,2006,38(1):55-57. 被引量：4
  • 3de Heer J,Pedersen J.The alpha cell expresses glucagon-like peptide-2 receptors and glucagon-like peptide-2 stimulates glucagon secretion from the rat pancreas[J].Diabetologia,2007,50:2135～2142.
  • 4Drucker D J,Yusta B,Boushey R P,et al.Human[Gly2]GLP-2 reduces the seveity of colonic injury in a murine experimental coli tis.Am J Physiol,1999,276:79 ～ 91.
  • 5Drucker D J.Glucagon-like peptides[J].Diabetes,1998,47(2):158～169.
  • 6Irwin D M,Wong K.Volution of new hormone functlon:Ioss and gain of a receptor[J].Heredity,2005,96(3):205～211.
  • 7Liu X W,David W N.Synergistic effect of supplemental enteral nutrients and exogenous glucagon-like peptide 2 on intestinal adaptation in a rat model of short bowel syndrome[J].Americon Journal of Clinical Nutrition,2006,84:1142 ～ 1150.
  • 8Tianru J.Mechanisms underlying proglucagon gene expression[J].Endocrinology,2008,15 (9):17 ～ 28.
  • 9Alison H,Robert A.Increased expression of specinc intestinal amino acid and peptide transporter mRNA in rats fed by TPN is reversed by GLP-21[J].Nutrient-Gene Interactions,2004,134:2957～2964.
  • 10Brubaker P L,Drucker D J.Minireview:Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas,gu,and central nervous system[J].Endocrinology,2004,145 (6):2653～2659.

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饲料工业
2006年 第23期

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