摘要
目的探讨热休克蛋白70(HSP70)和热休克蛋白27(HSP27)在宫颈鳞癌中的表达及其相关性。方法应用免疫组织化学方法检测HSP70、HSP27在60例宫颈鳞癌,18例宫颈上皮内瘤变(C IN),7例正常宫颈组织中的表达。结果宫颈鳞癌组织中HSP70,HSP27阳性表达率与正常宫颈组织相比差异有统计学意义(P<0.05);宫颈鳞癌中HSP70的阳性表达与病理分级、临床分期、淋巴结转移密切相关(P<0.05),HSP27的阳性表达与病理分级密切相关(P<0.05);HSP70与HSP27在宫颈鳞癌中的表达无相关关系(P>0.05)。结论HSP70、HSP27均在宫颈鳞癌发生和发展中起重要作用,HSP70可能作为判断宫颈癌预后的重要指标。
Objective To explore the expressions of HSP70 and HSP27 in cervical squamous cell carcinoma and their correlation. Methods Immunohistochemical method for HSP70 and HSP27 were performed on 60 cases of cervical squamous carcinomas,18 cases of cervical intraepi the lial neoplasia （CIN） and 10 cases of norreal cervical tissues. Results In cervical squamous cell carcinoma, the expression of HSP70 and HSP27 were significantly higher than that of normal cervical tissues ; the expression of HSP70 was significantly correlated with the pathological grade, clinical stages and lymph node metastasis ,the expression of HSP27 was significantly correlated with the pathological grade; the expression of HSP70 was not correlated with HSP27. Conclusion HSP70 and HSP27 should play an important role in the genesis and development of cervical squamous cell carcinoma;HSP70 can be the important target in predicting the prognosis of cervical squamous cell carcinoma.
出处
《中原医刊》
2006年第24期4-6,共3页
Central Plains Medical Journal
基金
河南省医学科技创新人才工程项目(200303056)
关键词
宫颈癌
热休克蛋白70
热休克蛋白27
Cervical carcinoma
Heat shock protein 70
Heat shock protein 27
