尘肺舒胶囊的药效学试验研究

Pharmacodynamic study of Chenfeishu Capsules

目的探讨尘肺舒胶囊临床疗效的机制。方法本实验采用健康大鼠、小鼠分别考察了尘肺舒胶囊治疗尘肺、止咳、化痰、平喘及体内炭粒廓清功能的药效学。结果尘肺舒胶囊能抑制实验性尘肺病变的发展;明显提高网状内皮系统的吞噬能力,提高机体非特异性免疫功能,增强机体抗病能力;明显延长浓氨水引发小鼠咳嗽的潜伏期,减少咳嗽次数;显著增强小鼠气管段排泌酚红的作用;明显延长喷雾磷酸组胺引起的豚鼠哮喘潜伏期。结论试验结果表明,尘肺舒胶囊具有补肺益肾、平喘止咳的功效。

OBJECTIVE To investigate the pharmacodynamics of Chenfeishu Capsule. METHODS The experiments used healthy rats and mouse to investigate the pharmacodynamics of Chenfeishu Capsule, which included treating lithicosis, stopping coughing, eliminating sputum, anti-asthma and sweepping away the charcoal remained in body. RESULTS Chenfeishu Capsule could inhibited the development of experimental silicosis; obviously improved the endothelial system, and improve the non-specific immune function, increase disease resistance; prolonged the incubation period of cough caused by strong aqua ,can significantly reduce coughing frequency; trachea of the mice significantly increased excretion of phenol red,significantly prolong the incubation period of asthma. CONCLUSION The results showed that Chenfeishu capsule could invigorating lung and had antibechic and antiasthmatic action.