摘要
Pterocaryquinone，新奇 1,4-naphthoquinone 衍生物，从 Pterocarya tonkinesis 被孤立，它的结构被分光镜的方法阐明。Pterocaryquinone 是与二枚五成员的碳戒指有一架 pentacyclic 骨骼的新二聚的 1,4-naphthoquinone 衍生物，它为 1,4-naphthoquinone 衍生物提供了一架新奇结构的骨骼并且向老鼠癌症 tsFT210 房间显示出导致 apoptosis 活动。
Pterocaryquinone, a novel 1,4-naphthoquinone derivative, was isolated from Pterocarya tonkinesis and its structure was elucidated by spectroscopic methods. Pterocaryquinone is a new dimeric 1,4-naphthoquinone derivative having a pentacyclic skeleton with two five-membered carbon rings, which provided a novel structural skeleton for 1,4-naphthoquinone derivatives and showed apoptosis-inducing activity toward mouse cancer tsFT210 cells.
基金
Project supported by the National Natural Science Foundation of China for Distinguished Young Scholars （No. 39825126）, the 973-project from Ministry of Science and Technology （No. 1998051113）, and the Fund for Cheung Kong Scholar from the Cheung Kong Scholars Program of Minis- try of Education of China.
Acknowledgments We thank Prof. Q. Sun and Mrs. G. Qu, both of Shenyang Pharmaceutical University, China, for their contributions on the collection and identification of the plant materials. Dr. H. 0sada, head of the Antibiotics Laboratory, the Institute of Physical and Chemical Re- search （RIKEN）, Japan, kindly provided the tsFT210 cell line.
关键词
东京枫杨
提取
药物
萘醌
苯醌
化学结构
细胞凋亡
Pterocarya tonkinesis, naphthoquinone, pterocaryquinone, chemical structure, apoptosis
