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缺氧诱导因子-1α与消化系肿瘤

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摘要 缺氧诱导因子（HIFs）是调节细胞适应缺氧的一个主要调控因子，存在三种亚型：HIF-1、HIF-2、HIF-3，其中HIF-1和HIF-2与肿瘤的血管生成关系密切。HIF-1由α亚单位和β亚单位组成异源二聚体，α亚单位是主要氧调解亚单位。在缺氧条件下，HIF-1α的DNA结合活性和HIF-1α蛋白水平增加。本文就HIF-1α的结构、功能、调控机制和在消化系肿瘤中的表达及其相关的治疗措施作一综述。
作者 杜琰萍 施瑞华
机构地区 南京医科大学第一附属医院消化内科
出处 《胃肠病学》 2006年第11期689-692,共4页 Chinese Journal of Gastroenterology
关键词 缺氧诱导因子-1Α 消化系肿瘤 HIF-1α DNA结合活性 调控因子 Β亚单位 Α亚单位 异源二聚体
分类号 R735 [医药卫生—肿瘤]
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参考文献40

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胃肠病学
2006年 第11期

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