摘要
目的了解经血感染人类免疫缺陷病毒1型(HIV-1)患者合并感染乙型肝炎病毒(HBV)及丙型肝炎病毒(HCV)的情况及发病特点。方法回顾性分析128例经血感染HIV患者合并感染HBV和HCV的感染率、肝脏表现及部分免疫学特征。结果128例患者中,单纯合并HCV感染者107例(83.6%),其中40例(31.3%)出现肝功能异常或肝损害,15例(11.7%)合并肝炎症状;单纯合并HBV感染3例(2.3%),均出现肝功能异常和肝炎症状;HIV、HBV、HCV三重感染7例(5.5%),无1例存在肝功能异常和肝炎症状;11例(8.6%)患者未合并HBV或HCV。结论经血感染HIV的患者与HCV的合并感染率高于与HBV的合并感染率,HIV合并HCV感染与HBV感染的临床转归也存在差异。
Objective To analyze the clinical features of 128 acquired immunodeficiency syndrome (AIDS) patients infected through blood transmission who were coinfected with hepatitis B virus (HBV) and hepatitis C virus (HCV). Methods The prevalence, liver functions, and some immunological profiles of 128 AIDS patients coinfected with HBV and HCV were retrospectively analyzed. Results Among the 128 AIDS patients, 107 (83.6%) were coinfected with HCV, among which 40 (31.3%) patients had abnormal liver functions or liver damage and 15 ( 11.7% ) patients experienced hepatitis symptoms. Three (2. 3% ) AIDS patients were singly coinfected with HBV, and all of them had abnormal liver functions and hepatitis symptoms. Seven (5.5 % ) patients were coinfected with HIV/HCV/HBV and none of them had abnormal liver functions or hepatitis symptoms. Eleven (8.6%) patients were only infected with HIV. Conclusions The prevalence of blood-transmitted HIV patients coinfected with HCV is higher than with HBV. The clinical outcomes of HIV coinfection with HCV and HBV are different.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2006年第5期662-664,共3页
Acta Academiae Medicinae Sinicae