通脉活血灵胶囊中大黄素在大鼠血浆中的浓度及药代动力学研究

Determination of emodin from tongmaihuoxueling capsules and study of its pharmacokinetics in plasma of rats

目的观察大鼠口服通脉活血灵胶囊后，其效能成分大黄素在大鼠体内的药动学过程。方法大鼠单次灌服通脉活血灵胶囊，用反相高效液相法测定不同时间的血药浓度，采用DAS2．0药动学软件拟合处理该药的药动学参数。结果通脉活血灵胶囊中大黄素在大鼠体内的药动学参数为：T1/2α、T1/2β、AUC（0-∞），K10、K12、K21、Tmax、Cmax分别为0．215、14．926、1296．845、0．191、2．279、0．808、0．33、145．37。结论单次灌服通脉活血灵胶囊后，大黄素在大鼠体内的药动学过程符合开放型二室模型，吸收快、消除慢。上述药动学过程同服用单味大黄后大黄素在家兔体内的药动学过程及服用含有大黄素的复方制剂后在大鼠体内的药动学过程有一定的差异。

Objective To study the pharmacokinetics of emodin after ig administration of Tongmaihuoxuehng Capsules（TC） in rats. Methods The concentrations of emodin in plasma after single ig administration of TC were determined by RP-HPLC method. The parameters of pharmacokinetics were computed by DAS 2.0 program. Results The pharmacokinetic parameters of emodin from TC in rats were as follows ： T 1/2α T 1/2β AUC （ 0- ∞）, K10, K12, K21 , Tmax,Cmax： 0.215,14.926,1296.845,0.191,2.279,0.808,0.33,145.37.Conclusion After single ig administration of TC in rats, the concentration-time curves of emodin in plasma fitted a two-compartment open model. The pharmacokinetic of emodin in TC showed a rapid absorption and slow elimination process in rats, which is different from the pharmacokinetic of emodin after ig administration of rhubarb in rabbits and compound preparation of rhubarb in rats.