淀粉与聚乳酸接枝共聚物的制备与表征

Preparation and Characterization of Starch-polylactide Copolymers

采用三甲基硅烷基(TMS)保护淀粉作为大分子引发剂,辛酸亚锡催化,制备聚乳酸与淀粉的接枝共聚物。红外光谱和核磁共振氢谱分析证实了共聚物的形成。接触角测试结果表明亲水性糖基的引入使共聚物具有较好的亲水性。在pH=7.2的PBS缓冲液中,共聚物膜能较快降解,6d后失重率接近50%,10d后完全降解。对聚乳酸进行糖基化改性,将大大拓展聚乳酸类材料在生物医学领域的应用范围。

Polylactide （PLA）-grafted starch copolymers were synthesized successfully by a bulk polymerization reaction using the trimethylsilyl-protected （TMS） starch as macroinitiator and stannous octoate as catalyst when starch was degraded previously, FT-IR and ^1H NMR were used to characterize the copolymer molecular structure. The results of contact angle determination showed that PLA-starch copolymer were more hydrophilic than pure PLA because of the introduction of glycosyl. The copolymer films degraded in higher rate than PLA in the PBS solution which pH = 7.2, its weight loss percent reached nearly 50% after 6 days and degraded completely after 10 days. The results demonstrate that glycosylation PEA polymeric materials would have more potential in biomedical application than PLA.