激光熔覆生物陶瓷涂层生物相容性体内研究

In Vivo Biocompatibility of the Bioceramic Coating Cladded by Laser

将激光熔覆原位合成的钙磷涂层及TC4分别植入健康的Mongrel成年狗,术后15天、60天和180天观察涂层与基材、涂层与机体组织的结合形态及植入后对动物的组织影响。此外,用涂层材料进行肌肉植入实验,分别在15天、37天、60天和180天观察其组织生长形态。结果表明:激光熔覆原位合成的钙磷涂层在动物体内其表面有新骨产生,说明了涂层材料在机体内具有诱导骨生成的生物活性;观察动物的植入部位无感染,无组织吸收或增生等不良反应,材料与肌肉间未发现有不良反应,材料与肌肉界面覆盖的结缔组织层随种植时间延长而增厚。激光熔覆原位合成的钙磷涂层具有良好的体内生物相容性和活性,是一种体内生物陶瓷涂层材料。

Aim of this study is to check whether calcium phosphate （Ca-P） coatings with main HA composition by laser cladding present in vivo good biocompatibility. TC4 alloy with the laser coating and without this coating, respectively, were carefully implanted into the femur bone and thigh muscles of adult Mongrel healthy dogs to observe physiological condition of these dogs＇ tissues. These results show the Ca-P laser coatings could induce growth of new bone, presenting bioactivity, and also had no in vivo toxicity for the dogs. Besides, dogs, in whom the Ca-P laser coatings were implanted, have well-balanced physiology activity. The Ca-P coating by laser cladding is testified to be in vivo biocompatible ceramics with bioactivity.