调控性SNPs
摘要
人类遗传学的一个重要问题是如何鉴别那些能改变基因表达水平的多态性.通过对不同个体外显子序列的重新测序,可较容易地将编码区的多态性进行分类[1],而调控性SNPs因陷于基因附近的多态性"海洋"中,很难被准确描述[2].因此需要很多不同的策略来建立调控性多态的数据库.
出处
《中国分子心脏病学杂志》
CAS
2003年第4期254-255,共2页
Molecular Cardiology of China
参考文献14
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1[1]Cargill M,Altshuler D, Ireland J,et al. Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat Genet,. 1999 Jul; 22 (3) :231-8.
-
2[2]Sachidanandam R,Weissman D, Schmidt SC, et al. A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature. 2001 Fed 15;409 (6822) :928-33.
-
3[3]Brem RB, Yvert G, Clinton R, et al. Genetic dissection of transcriptional regulation in budding yeast. Science. 2002Apr 26; 296 (5568) :752-5.
-
4[4]Cheung VG, Conlin LK, Weber TM, et al. Natural variation in human gene expression assessed in lymphoblastoid cells. Nat Genet. 2003 Mar;, 33 (3) :422-5.
-
5[5]Wasserman WW, Palumbo M, Thompson W, et al. Human-mouse genome comparisons to locate regulatory sites. Nat Genet. 2000 Oct; 26 (2) :225-8.
-
6[6]Rockman MV, Wray GA. Abundant raw material for cis-regulatory evolution in humans. Mol Biol Evol. 2002 Nov;19 (11) :1991-2004.
-
7[7]Knight JC, Keating B J, Rockett KA, et al. In vivo characterization of regulatory polymorphisms by allele-specific quantification of RNA polymerase loading. Nat Genet. 2003Apr; 33 (4) :469-75.
-
8[8]Ozaki K, Ohnishi Y,Iida A, et al. Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction. Nat Genet. 2002 Dec; 32 (4) :650-4.
-
9[9]Daly M J, Rioux JD, Schaffner SF, et al. High-resolution haplotype structure in the human genome. Nat Genet.2001 Oct; 29 (2) :229-32.
-
10[10]Rioux JD, Daly MJ, Silverberg MS, et al. Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease. Nat Genet. 2001 Oct; 29 (2) :223-8.
-
1病原真菌[J].国外科技资料目录(医药卫生),2002(10):18-19.
-
2孔辉,朱虹光.microRNA的功能研究流程及常用技术[J].中华病理学杂志,2012,41(12):858-861.
-
3梅俊,程卓刚,谢雯.生长激素对培养的下丘脑细胞发育及衰老的调控性影响[J].西安医科大学学报,1997,18(3):279-285. 被引量:1
-
4庞秋霞,马晓琴,许静洪.MicroRNA的生物学作用及临床意义[J].延安大学学报(医学科学版),2013,11(3):25-28. 被引量:5
-
5孙小杰,胡何节.血管内皮祖细胞与调控性细胞因子[J].国际外科学杂志,2007,34(12):831-834. 被引量:2
-
6王菲菲,刘新光,梁念慈.微小RNA:一类新的调控性非编码RNA[J].国外医学(临床生物化学与检验学分册),2005,26(11):788-791. 被引量:3
-
7宋士军,徐瑛,李芳芳,张丽华,张翼,王世杰.黄芩舒张大鼠离体胸主动脉环作用的研究[J].陕西中医,2009,30(8):1083-1086.
-
8徐婉婷(综述),孔宪明,曹兰芳(审校).自然杀伤细胞在免疫反应中的调控作用[J].国际儿科学杂志,2011,38(4):413-415.
-
9毕晟,丁有权,齐建国.蠕虫及蠕虫源性免疫调控性分子应用于自身免疫性疾病治疗的研究进展[J].细胞与分子免疫学杂志,2016,32(9):1276-1279. 被引量:3
-
10夏萍,张正华,郑志忠.微小RNA在皮肤发生和疾病中的作用[J].中华临床医师杂志(电子版),2010,4(3):57-60. 被引量:2