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原发性高血压基因治疗 被引量:2

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摘要 高血压是困扰全球的重要疾病,它显著增加多种心血管疾病的危险性,包括脑卒中、冠心病、心力衰竭、心律失常、心肌病等.除部分继发性高血压患者可以进行手术、介入或特殊药物治疗外,占大多数的原发性高血压(EH)患者需要服用降压药物.传统降压药物治疗经大规模临床药物试验及多年临床应用,证明其降压作用可靠,对高血压患者近期及远期预后均有良好作用.但也存在如下缺点:
机构地区 中国医学科学院
出处 《中国分子心脏病学杂志》 CAS 2003年第6期363-366,共4页 Molecular Cardiology of China
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  • 1[1]Chao J, Chao L. Experimental kallikrein gene therapy in hypertension, cardiovascular and renal disease. Pharmacol Res. 1997; 35:517-522
  • 2[2]Lin KF, Chao J, Chao L. Prolonged reduction of high blood pressure with human nitric oxide synthase gene delivery. Hypertension. 1997; 30:307-313
  • 3[3]Chao J, Jin L, Lin KF et al. Adrenomedullin gene delivery reduces blood pressure in spontaneously hypertensive rats. Hypertens Res. 1997;20:2692-2677
  • 4[4]Lin KF, Chao J, Chao L. Atrial natriuretic peptide gene delivery attenuates hypertension, cardiac hypertrophy, and renal injury in salt-sensitive rats. Hum Gene Ther. 1998;9:1429-1438
  • 5[5]Dobrzynski E, Yoshida H, Chao J et al. Adenovirusmediated kallikrein gene delivery attenuates hypertension and protects against renal injury in deoxydcorticosterone-salt rats.Immunopharmacology. 1999; 44:57-65
  • 6[6]Emanueli C, Salis MB, Stacca T et al. Rescue of impaired angiogenesis in spontaneously hypertensive rats by intramuscular human tissue kallikrein gene transfer. Hypertension. 2001 Jul;38 (1) :136-41
  • 7[7]Zhao C, Wang P,Xiao X et al. Gene Therapy With Human Tissue Kallikrein Reduces Hypertension and Hyperinsulinemia in Fructode-Indeced Hypertensive Rats. Hypertension. 2003 Oct 20 [Epub ahead of print] .
  • 8[8]Zhang YC, Bui JD, Shen L et al. Antisense inhibition of β1-adrenergic receptor mRNA in a single dose produce a profound and prolonged reduction in high blood pressure in spontaneously hypertensive rats. Circulation. 2000; 101:682-688
  • 9[9]Kumai T, Tateishi T, Tanaka M. Tyrosine hydroxylase antisense gene therapy causes hypotensive effects in the spontaneously hypertensive rats. J Hypertens. 2001 Oct; 19 (10) :1769-73
  • 10[10]Kishioka H, Fukuda N, Wen-Yang H et al. Effects of PDGF A-chain antisense oligodeoxynucleotides on growth of cardiovascular organs in stroke-prone spontaneously hypertensive rats. Am J Hypertens. 2001 May; 14 (5 Pt 1) :439-45

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