摘要
利用片断合成法合成了具有DNA切割能力的六聚吡咯/丝组缀合物,检测了该化合物的1H、13C NMR和ESI-MS/MS图谱,确证了该化合物的结构,通过1H-1H COSY,HSQC,HMBC等2D NMR技术对其1H和13C NMR数据进行了归属和解析,并探讨了其ESI-MS/MS质谱裂解规律.
A hexpolyamide/seryl-histidine dipeptide coniugate DNA cleavage agent was synthesized and its structure was elucidated by NMR and ESI-MS/MS methods. Com- plete assignment of ^1 H and ^13C NMR chemical shifts of the compound was obtained using 2D NMR techniques, including 1^H-^1H COSY, HSQC and HMBC. The MS/MS fragmentation pathways of the polyamide/peptide conjugate are also discussed.
出处
《波谱学杂志》
CAS
CSCD
北大核心
2006年第4期509-515,共7页
Chinese Journal of Magnetic Resonance
基金
国家自然科学基金资助项目(20572061和20602032)
