5Bacon A,Makin J,Sizer PJ,et al.Carbohydrate Biopolymers Enhance Antibody Responses to Mucosally Delivered Vaccine Antigens.Infection and Immunity,2000,68(10):5764
6Mills KH,Cosgrove C,McNeela EA,et al.Protective levels of diphtheria-neutralizing antibody induced in healthy volunteers by unilateral priming-boosting intranasal immunization associated with restricted ipsilateral mucosal secretory immunoglobulin a.Infection and Immunity,2003,71 (2):726
7Seferian PG,Martinez ML.Immune stimulating activity of two new chitosan containing adjuvant formulations.Vaccine,2000,19(6):661
8Bivas-Benita M,Laloup M,Versteyhe S,et al.Generation of Toxoplasma gondii GRA1 protein and DNA vaccine loaded chitosan particles:preparation,characterization,and preliminary in vivo studies.Int J Pharm,2003,266(1～2):17
9McNeela EA,O' Connor D,Jabbal-Gill I,et al.A mucosal vaccine against diphtheria:formulation of cross reacting material (CRM197)of diphtheria toxin with chitosan enhances local and systemic antibody and TH2 responses following nasal delivery.Vaccine,2000,19(9-10):1188
10Kang ML,Kang SG,Jiang HL,et al.In vivo induction of mucosal immune responses by intranasal administration of chitosan microspheres containing Bordetella bronchiseptica DNT.Eur J Pharm Biopharm,2006,63(2):215
6McNeela EO, Connan D, Jabbal-Gill I, et al. Mucosally delivered vaccine against diphtheria; formulation of cross reacting material (CRM197) of diphtheria toxin with chitosan enhances local and systemic antibody and Th2 responses following nasal delivery.
7Ilium L,Watts P,Fisher AN,et al. Novel chitosan based delivery systems fornasal administration of a LHRH-analogue. STP Pharma,2000, 10:89-94.
8Illum L, Jabbal-Gill I,Hinchcliffe M,et al. Chitosan as a novel nsal delivery system for vaccines. Advanced Arug Delivery Reviews, 2001,51:81-96.
9Roy K,Hai QM,Shau KH, et al. Oral gene delivery with chitosan-DNA nanoparticles generates immunologic protection in a murine model of peanut allergy. Nature Med, 1999,5:387-391.
10Chen Z, Shin-tesu K, Yukari H, et al. Cross-protection against a lethal influenza virus infection by DNA vaccine to neuraminidase. Vaccine,2000,18:3214-3222.
