茶多酚抗移植性乳腺癌作用的研究

Anticancer effect of tea polyphenols on implanted breast cancer

目的观察茶多酚对移植性小鼠乳腺癌(EMT_6)生长的抑制作用,为进一步开展茶多酚抗肿瘤新生血管形成研究提供依据。方法小鼠可移植性乳腺癌(EMT_6)细胞系经传代培养后,对纯系BALB/c小鼠进行肿瘤移植,以茶多酚进行干预性治疗,通过抑瘤率评价茶多酚对EMT_6生长的抑制作用。结果茶多酚灌胃和局部注射组对EMT_6的抑瘤率分别为37．43%、40．94%。结论茶多酚对EMT_6生长具有明显的抑制效果。

Objective To observe the growth inhibiting effect of tea polyphenols on implanted mouse breast cancer（EMT6）, and offer the foundation for the next study on its inhibiting angiogenesis effect and its molecular mechanism. Methods Mammary adenocarcinoma EMT6 was cultured and propagated, then implanted on female BALB/c mice. Tea polyphenols was peroral administrated and local injected. Anticancer function was determined with regular methods. Result After tea polyphenols were taken by oral and local injection on EMT6 mammary adenocarcinoma mice, the inhibitory ratio of tumor are respectively 37.43% and 40.94%. Conclusion Tea polyphenols had significant inhibitive effect on implanted breast cancer. This offered the foundation for the next intensive study on its inhibiting angiogenesis effect and its molecular mechanism.