多官能团分枝状化合物的合成研究Ⅰ．三方向醚键型分枝状化合物的合成

Synthesis of Multifunctional Groups and Multibranched Compounds Ⅰ. Synthesis of Three directional Ether bond Branched Compounds

报道新型有机分子——三方向醚键型分枝状化合物的合成。目标化合物的合成选用甘油为三方向起始核心，以氧丙基为空间间隔基，通过延伸方法解决甘油末端羟基的立体位阻。甘油末端羟基经氰乙基化、醇解、还原和磺酸酯化等步骤制得化合物（４），（４）分别与３种不同的带保护基的分支侧链（１～３）成醚得化合物（５～７），（５～７）脱保护后得羟基数为原母核２倍的醚键型分枝状化合物。所合成的化合物（５～１０）均未见文献报道，其结构经ＩＲ、１Ｈ－ＮＭＲ和元素分析确证。它们可用于新型多分枝大分子——Ｃａｓｃａｄｅ分子的合成研究。

New organic molecules the three directional ether bond branched compounds were designed and synthesized. Glycerol used as three directional initiator core was oxypropylated first to decrease steric hindrance. The core(4) reacted respectively with three branched building blocks (1 3) by etherification, followed by deprotection to give title compounds (8 10). The number of the hydroxyl group of the compounds (8 10) are twice as that of initiator core. The structure of all new compounds (5 10) were confirmed by IR, 1H NMR and elemental analysis. These syntheses can be used in the study of new starburst dendritic macromolecules cascade mlecules.