聚氰基丙烯酸正丁酯毫微球的电学特性研究

The Electricity Properties of Polybutylcyanoacrylate Nanoparticles

采用Ｕ型管电泳法研究作为药物载体的聚氰基丙烯酸正丁酯毫微球的电学特性。研究表明：聚氰基丙烯酸正丁酯毫微球荷负电；其表面动电位与稳定剂浓度和ｐＨ值呈正相关；和载体材料的加量呈负相关；稳定剂和表面活性剂种类对表面动电位有影响；离子强度的影响呈非线性关系；而实验条件下电解质的影响不明显；模型药物（庆大霉素）的加入可使表面动电位下降。本研究为载药毫微球制备工艺的建立奠定了基础。

Electricity properties of polybutylcyanoacrylate nanoparticles (PBCA NP) were studied by using a U tube electrophoresis apparatus.It was proved that all the PBCA NP is negatively charged. The surface potential of PBCA NP is directly proportional to the concentration of stabilizer (Dextran 70) and the pH value of the medium,while it is inversely proportional to the concentration of butylcyanoacrylate and the model drug(gentamycin).The effect of ion strength on surface potential is obvious but not linear.The effect of stabilizers and surfactants used on the surface potential is evident while the effect of electrolytes is indistinct under the experimental conditions.