中国822例肢体短缩畸形分析

Analysis of 822 Infants with Limb Reduction Defect in China

为了解我国肢体短缩畸形（ＬＲＤ）的基本状况，采用以医院为基础的监测方法，对１９８６年１０月至１９８７年９月全国２９省（市、自治区）９４５所医院收集的８２２例ＬＲＤ围产儿进行了分析。结果表明：全国ＬＲＤ发生率为６．６／万，云南、贵州、福建和江西省显著高于全国水平（Ｐ＜０．０５），上海市的发生率低于全国水平（Ｐ＜０．０１）。低体重儿中ＬＲＤ发生率高于正常体重组（Ｐ＜０．００１）。乡村与城镇发生率存在差异（Ｐ＜０．００１），患儿无性别差异。畸形以四肢受累最为常见；上肢受累高于下肢（Ｐ＜０．００１），左右侧无差异（Ｐ＞０．０５）。２４．２％的患儿为单发ＬＲＤ，伴有其它畸形的发生率为７５．８％。

This work is aimed at the basic condition of infants with limb reduction defect (LRD) in China.822 cases of LRD occurring among 1243 284 live and stillbirths of 28 or more gestation weeks in China from Oct.1986 to Sept.1987 were analysed.The overall prevalence of LRD was 6.6 per 10000 ranging from 14.4 per 10 000 to 3.6 per 10 000. No sex difference was observed.The prevalence of LRD in infants with low birthweight was significantly higher than that in infants with normal birthweight ( P <0.001).Also the prevalence of LRD in rural area was higher than that in urban area ( P <0 001). Four limb involvement was most common.The cases with only upper limb involvement (278/451,61,6%) were significantly more prevalent than those with only lower limb involvement (173/451,38.4%, P <0 001),but no difference was found between the left LRD and right LRD ( P >0 05),nor was a significant difference noted between single LRD and multiple LRD.75.8% of the infants with LRD had defects in other systems.