原发性肾病综合征患儿白细胞介素－6变化及免疫状态的探讨

Interleukin 6 and Immune State in Children with Mephrotic Syndrome

采用ＭＨ６０细胞对ＩＬ－６活性检测发现，ＩＮＳ患儿发作期ＩＬ－６活性较正常对照组显著性升高（Ｐ＜０．０１），ＩＬ－６活性与２４小时尿蛋白呈直线正相关。ＣＤ＋３细胞及ＩｇＧ显著性下降，单纯性肾病ＣＤ＋８细胞明显升高，ＣＤ＋４／ＣＤ＋８比值明显下降，表明ＩＮＳ患儿存在ＩＬ－６活性升高为主要表现的免疫功能紊乱，并提示ＩＬ－６是促进发病的重要因素。

IL 6 activities were determined in 37 children with idiopathic nephrotic syndrome(INS) by using an IL 6 dependent murine hybridoma clone(MH 60 ).The results showed that the leveles of IL 6 activities in children with INS at the stage of onset were significantly higher than those of normal control group ( P <0.01), and the levels of IL 6 activities had positive correlation with the levels of urinary protein in 24 hours.The levels of IL 6 activities decreased remarkably at the stage of remission.CD + 3 cells and the levels of serum IgG decreased significantly in those with INS;CD + 8 cell increased and CD + 4/CD + 8 cell ratio decreased obviously in those with the simple nephrotic syndrome(SNS) at the stage of onset as compared with normal control group.These results indicate that there are immune disorders characterized by increased level of IL 6 activity in INS and suggest that IL 6 plays an important role in the development of INS.