摘要
采用国产药用辅料,运用均匀设计方法对阿司匹林分散片处方进行筛选,给出三种崩解剂或溶胀性辅料占处方的比例分别为5%,7%,5%.经过对优选处方的实验表明:崩解时间小于3min,分散均匀性试验能通过710μm筛网,均达到英国药典(1993年版)要求;体外溶出试验表明:T50=1.161min,Td=2.109min,与阿司匹林普通片溶出参数比较有显著差异,分散片溶出速度快,30min内几乎全部溶出.
Using uniform design method,we selected Chinese make excipients for Dispersible Aspirin Tablets,and established three percentages of excipients:5%,7%,5%.The results show that:when disintegration time<3 min,uniforminty of dispersion is up to the standard of B.P.1993.The results of disollution are:T50=1.161min,Td=2.109min.The disollution rate of Dispersible Aspirin Tablets is faster than that of Aspirin Tablets.All parts of Aspirin in dispersible tablets are disolluted in about 30 min.
出处
《沈阳药科大学学报》
CAS
CSCD
1996年第4期235-239,共5页
Journal of Shenyang Pharmaceutical University
关键词
阿司匹林
分散片
均匀设计
处方筛选
溶出度
Aspirin
Dispersiable tablets
Uniform design
Selection of excipients
Disollution