利用均匀设计筛选阿司匹林分散片处方

SELECTION OF EXCIPIENTS FOR DISPERSIBLE ASPIRIN TABLETS BY UNIFORM DESIGN

采用国产药用辅料，运用均匀设计方法对阿司匹林分散片处方进行筛选，给出三种崩解剂或溶胀性辅料占处方的比例分别为５％，７％，５％．经过对优选处方的实验表明：崩解时间小于３ｍｉｎ，分散均匀性试验能通过７１０μｍ筛网，均达到英国药典（１９９３年版）要求；体外溶出试验表明：Ｔ５０＝１．１６１ｍｉｎ，Ｔｄ＝２．１０９ｍｉｎ，与阿司匹林普通片溶出参数比较有显著差异，分散片溶出速度快，３０ｍｉｎ内几乎全部溶出．

Using uniform design method,we selected Chinese make excipients for Dispersible Aspirin Tablets,and established three percentages of excipients:5%,7%,5%.The results show that:when disintegration time<3 min,uniforminty of dispersion is up to the standard of B.P.1993.The results of disollution are:T50=1.161min,Td=2.109min.The disollution rate of Dispersible Aspirin Tablets is faster than that of Aspirin Tablets.All parts of Aspirin in dispersible tablets are disolluted in about 30 min.