肝硬化、肝癌患者乙型及丙型肝炎病毒的检测

Hepatitis B and C Viral Infections in Patients with Liver Cirrhosis and Hepatocellular Carcinoma

对41例肝硬化病人,40例肝癌病人及41例非肝炎、非肝硬化及非肝癌病人(对照组)进行血清乙肝 5项(HBsAg、抗 HBs、抗 HBc、HBeAg、抗 HBe)、血清抗HCV及血清 HCV RNA检测.结果:肝硬化组、肝癌组和对照组乙肝 5项检出率分别为:92.7%、95.0%和 31.7%;抗HCV检出率分别为 31.7%、12.5%和 9.7%;HCV RNA检出率分别为:36.6%、27.5%和 14.6%.通过比较分析认为肝硬化、肝癌的发生可能与HBV感染密切相关,与HCV感染可能也有关,但HCV病因意义不如HBV显著.

The prevalence of hepatitis B and C virus infections was studied in 41 cases with liver cirrhosis and 40 with hepatocellular carcinoma. 40 cases with no hepatitis,no liver cirrhosis and no hepatocellular carcinoma were as controls. In addition to serum HBsAg, Anti-HBs, Anti-HBc,HBeAg,anti-HBe and hepatitis C virus antibodies,hepatitis C virus RNA were determined with a nested polymerase chain reaction assay. Among 41 patients with liver cirrhosis,38 (92. 7%)were positive for the five HBV markers, 13 (31. 7%)were positive for hepatitis C virus antibodies and 15(36. 6%)were positive for heptitis C virus RNA. Among 40 patients with hepatocellular carcinoma,38(95. 0%)were positive for the five HBV markers,5(12. 5%)were positive for hepatitis C virus antibodies and 11(27. 5%) were positive for hepatitis C RNA. Among 40 patients of the controls group,13(31. 7%)were positive for the five HBV markers, 4 (9. 7%) were positive for hepatitis C virus antibodies and 6(14. 6%) werepositive for hepatitis C virus RNA. We conclude that most of liver cirrhosis and hepatocellular carcinoma are related to HBV,part may be related to HCV,too, but Hepatitis B is more prevalent than hepatitis C virus.