西酞普兰与丙咪嗪治疗抑郁症对照研究

A comparative study of citalopram and imipramine in the treatment of depressive disorders

目的:比较西酞普兰与丙咪嗪治疗抑郁症的疗效及安全性。方法:将77例抑郁症患者随机分为两组,分别为西酞普兰组(41例)与丙咪嗪组(36例),疗程6周。用汉密尔顿抑郁量表(HAMD)及汉密尔顿焦虑量表(HAMA)在治疗前及治疗后2、4、6周评定疗效;用副反应量表(TESS)评定不良反应。结果:西酞普兰组显效率70.73%、有效率85.36%,丙咪嗪组显效率75.0%、有效率86.11%,两组间差异无显著性(P>0.05);不良反应方面,西酞普兰出现不良反应18例,丙咪嗪出现25例,两组间差异有显著性(P<0.01)。结论:西酞普兰是治疗抑郁症较为安全有效的药物。

Objective：To compare the clinic effects and the safety of citalopram and imipramine in treatment of depression. Methods：Seventy seven patients with depressive disorder were randomly divided into citalopram treatment （41 patients）and imipramine treatment（ 36 patients）for 6 weeks. The clinic effects and side effects were tested with HAMD, HAMA and TESS before treatment and 2, 4, 6 weeks after treatment respectively. Results： After 6 -week treatment, the significant improvement rate and response rate was 70.73% and 85.36% respectively in citalopram group, 75.0% and 86.11% respectively in imipramine group. There were no significant differences between two groups（ P 〉 0.05 ）. 18 patients had the side effects in citalopram group and 25 ones in imipramine group. There was statistically difference between two groups（ P 〈 0.01 ）. Conclusions： Citalopram has better efficacy and fewer side effects for depressive disorders.