西酞普兰治疗大中学生抑郁症对照研究

Comparative study of citalopram and amitriptyline in the treatment of high school students and undergraduates' depression

目的:比较西酞普兰与阿米替林治疗大中学生抑郁症的有效性及安全性。方法:收集在校大中学生抑郁症患者46例随机分为两组,分别给予西酞普兰与阿米替林治疗,疗程8周。用汉密尔顿抑郁量表(HAML)在治疗前及治疗2、4、6、8周评定疗效,用副反应量表(TESS)评定不良反应。结果:两组总体疗效相当,治疗第2周时,西酞普兰组有效率较高,在第8周时两组疗效差异无显著性。结论:西酞普兰起效稍快,不良反应较轻,安全性好,更适合在校大中学生抑郁症患者。

Objective：To explore clinical efficacy and safely of citalopram and amitriptyline in the treatment of high school students and undergraduates＇depression. Methods：46 patients of high school students and undergraduates with depression were treated randomly with citalopram or amitriptyline for eight weeks, and measured with Hamilton depressive scale （ HAMD）, and treatment emergent symptom scale （TESS） before treatment and 2,4,6,8 weeks after treatment. Results： The both drugs were similar in efficacy, The side effects of eitalopram were less. Conclusions： Citalopram had faster on effect, also demonstrated a better tolerability in the treatment of high school students and undergraduates＇s depression.