摘要
目的:比较西酞普兰与阿米替林治疗大中学生抑郁症的有效性及安全性。方法:收集在校大中学生抑郁症患者46例随机分为两组,分别给予西酞普兰与阿米替林治疗,疗程8周。用汉密尔顿抑郁量表(HAML)在治疗前及治疗2、4、6、8周评定疗效,用副反应量表(TESS)评定不良反应。结果:两组总体疗效相当,治疗第2周时,西酞普兰组有效率较高,在第8周时两组疗效差异无显著性。结论:西酞普兰起效稍快,不良反应较轻,安全性好,更适合在校大中学生抑郁症患者。
Objective:To explore clinical efficacy and safely of citalopram and amitriptyline in the treatment of high school students and undergraduates'depression. Methods:46 patients of high school students and undergraduates with depression were treated randomly with citalopram or amitriptyline for eight weeks, and measured with Hamilton depressive scale ( HAMD), and treatment emergent symptom scale (TESS) before treatment and 2,4,6,8 weeks after treatment. Results: The both drugs were similar in efficacy, The side effects of eitalopram were less. Conclusions: Citalopram had faster on effect, also demonstrated a better tolerability in the treatment of high school students and undergraduates's depression.
出处
《中国民康医学》
2006年第23期1009-1010,共2页
Medical Journal of Chinese People’s Health
关键词
西酞普兰
阿米林替
大中学生
抑郁症
Citalopram
Amitriptyline
High school students and undergraduats
Depression.