泰必利联用氯硝西泮治疗焦虑症临床观察

A clinical trial of tiapride combining with clonazepam in the treatment of Anxiety disorders

目的:探讨泰必利联用氯硝西泮治疗焦虑症的疗效和安全性。方法:将符合条件150例焦虑症患者随机分为泰必利联用氯硝西泮组(治疗组)和氯硝西泮组(对照组)各75例,治疗6周,采用汉密尔顿焦虑量表(HAMA)及副反应量表(TESS)评定疗效及不良反应。结果:治疗组6周末HAMA总分和躯体焦虑因子分减分率明显大于对照组,显效率明显优于对照组,不良反应则少于对照组。结论:泰必利联用氯硝西泮治疗焦虑症可以增加疗效、减少药物不良反应。

Objective： The purpose of this study is to investigate the efficacy of tiapride combining with clonazepam in the treatment of anxiety disorders. Methods ：150 patients with anxiety disorders were randomly treated with tiapride combining with clonazepam （n = 75 ） and clonazepam only （ n = 75）. Hamilton Anxiety Scale （HAMA） used and Treatment Emergent Symptom Scale （TESS） assess efficacy and adverse reactions. Results： Group 6 combined weekend HAMA scores and lower body anxiety factor sub - group showed significantly greater than clonazepam, Hin markedly higher than clonazepam Group, and adverse reactions less than clonazepam Group. Conclusions： It is suggested that tiapride combining with clonazepam have a superior and reduce adverse drug reactions in the treatment of anxiety disorders.